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Tacalcitol monohydrate is a vitamin D analogue applied to the skin. It is used to treat psoriasis vulgaris in adults by reducing excessive skin-cell production and inflammation.
Tacrolimus is a calcineurin-inhibitor immunosuppressant that reduces T-cell activity. It is mainly used after organ transplantation to prevent rejection or treat rejection not responding to other immunosuppressants. The selected intravenous product is for specialist hospital use.
Tacrolimus is a calcineurin-inhibiting immunosuppressant. Oral formulations help prevent or treat rejection after organ transplantation, while tacrolimus ointment treats selected people with moderate-to-severe atopic dermatitis.
Tadalafil is a phosphodiesterase type 5 inhibitor that relaxes certain blood vessels and smooth muscle. Selected UK products are licensed for erectile dysfunction or pulmonary arterial hypertension.
Tafamidis is a prescription transthyretin-stabilising treatment for adults with transthyretin amyloidosis affecting the heart. It is used for wild-type and hereditary transthyretin amyloidosis with cardiomyopathy alongside standard care.
Tafamidis meglumine is a transthyretin stabiliser used for adults with stage 1 symptomatic transthyretin amyloid polyneuropathy. It is intended to delay further peripheral nerve impairment rather than remove amyloid already deposited.
Tafasitamab is an antibody treatment that targets CD19 on B cells. In the UK, it is used with other treatments for certain adults with relapsed or refractory diffuse large B-cell lymphoma or follicular lymphoma.
Tafluprost is a prostaglandin analogue eye drop that lowers pressure inside the eye. It is licensed for adults with open-angle glaucoma and ocular hypertension.
This preservative-free eye-drop combination contains tafluprost, a prostaglandin analogue, and timolol, a beta blocker. It lowers pressure inside the eye in adults with open-angle glaucoma or ocular hypertension when either type of eye drop alone has not lowered pressure sufficiently.
Talazoparib tosylate is a targeted anticancer treatment called a PARP inhibitor. It is licensed for certain advanced HER2-negative breast cancers with an inherited BRCA mutation and, with enzalutamide, for metastatic castration-resistant prostate cancer when chemotherapy is not clinically indicated.
Talimogene laherparepvec is a genetically modified, weakened herpes simplex virus type 1 injected directly into melanoma lesions. It is used in selected adults whose melanoma cannot be removed surgically and has spread regionally or to certain distant sites without visceral disease.
Talquetamab is a bispecific antibody that helps T cells recognise and destroy multiple myeloma cells. It is used alone for adults whose myeloma has returned or stopped responding after several specified previous treatments.
Tamoxifen citrate is a selective oestrogen receptor modulator that blocks oestrogen signalling in breast tissue. It is mainly used to treat breast cancer and can reduce breast cancer risk in appropriately assessed women.
Tamsulosin hydrochloride is an alpha-blocker that relaxes muscle in the prostate and urethra. It mainly eases urinary symptoms caused by benign prostate enlargement, including weak flow, hesitancy, urgency and frequent urination.
Tapentadol hydrochloride is a strong opioid painkiller that also increases noradrenaline signalling involved in pain control. Selected products are licensed for moderate-to-severe acute pain or severe chronic pain when opioid analgesia is required.
Tapentadol is a strong opioid painkiller that also increases noradrenaline activity in pain pathways. The selected prolonged-release product is licensed for adults with severe chronic pain that can only be adequately managed with an opioid.
Tapentadol phosphate is a strong opioid painkiller that also increases noradrenaline activity in pain pathways. The selected prolonged-release products are licensed for severe chronic pain in adults when opioid treatment is needed.
Tapentadol tartrate is a strong opioid painkiller that also increases noradrenaline signalling involved in pain control. The selected prolonged-release product is licensed for severe chronic pain that can be adequately managed only with opioid analgesics, in adults and children over 6 years.
Tarlatamab is an antibody-based cancer treatment that helps T cells recognise and destroy small cell lung cancer cells. In the UK, it is used for adults whose cancer has progressed during or after platinum-based chemotherapy.
Tauroselcholic acid is a radiolabelled synthetic bile acid used only for diagnostic testing. Scans measure bile acid retention to help investigate bile acid malabsorption and related chronic diarrhoea.
Tea tree oil is an essential oil from Melaleuca alternifolia. The selected product is a traditional herbal medicinal product used on the skin, or diluted as a mouth rinse, for several minor conditions; these uses are based on traditional use rather than demonstrated clinical efficacy.
Tebentafusp is a targeted immunotherapy that brings T cells into contact with uveal melanoma cells displaying a specific gp100 target. In the UK, it is licensed as monotherapy for HLA-A*02:01-positive adults whose uveal melanoma cannot be removed surgically or has spread.
Teclistamab is a bispecific antibody that helps T cells recognise and destroy multiple myeloma cells. It is licensed alone for adults whose myeloma has returned and is resistant to treatment after specified previous therapies.
Tedizolid phosphate is an oxazolidinone antibiotic converted in the body to active tedizolid. It is used for acute bacterial infections of the skin and tissues beneath it, particularly those caused by susceptible Gram-positive bacteria.
Teduglutide is a glucagon-like peptide-2 analogue used for stable short bowel syndrome after surgery. It improves absorption of fluid and nutrients and may reduce the need for intravenous nutrition or fluids.
Teicoplanin is a glycopeptide antibiotic used mainly for serious infections caused by susceptible Gram-positive bacteria. Selected products are also licensed as an oral alternative for Clostridioides difficile-associated diarrhoea and colitis.
Telbivudine is a nucleoside analogue antiviral that suppresses hepatitis B virus replication. The selected product was indicated for certain adults with chronic hepatitis B and compensated liver disease, but is listed as discontinued.
Telmisartan is an angiotensin II receptor blocker that relaxes blood vessels and lowers blood pressure. In adults, it is licensed for essential hypertension and for reducing cardiovascular illness in certain people at high cardiovascular risk.
Temozolomide is an oral alkylating chemotherapy for particular malignant brain tumours. It is licensed with radiotherapy and then alone for newly diagnosed glioblastoma, and for recurrent or progressive malignant glioma after standard treatment.
Temsirolimus is a targeted anticancer treatment that inhibits mTOR, a protein involved in cell growth and division. It is licensed for selected adults with advanced renal cell carcinoma and relapsed or treatment-resistant mantle cell lymphoma.
Tenecteplase is a recombinant thrombolytic that dissolves fibrin within blood clots. In the UK, selected products are licensed for emergency hospital treatment of eligible adults with acute ischaemic stroke or certain acute heart attacks.
Tenofovir alafenamide fumarate is a nucleotide reverse transcriptase inhibitor antiviral and a prodrug of tenofovir. It suppresses chronic hepatitis B virus replication, helping to limit ongoing liver injury, but does not prevent transmission to others.
Tenofovir disoproxil reduces replication of HIV and hepatitis B virus. It is licensed for HIV treatment with other antiretrovirals and for specified patients with chronic hepatitis B.
Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor that reduces replication of HIV and hepatitis B virus. It is used with other antiretrovirals for HIV and may be used for chronic hepatitis B.
Tenofovir disoproxil succinate is an antiviral nucleotide analogue used with other antiretrovirals for HIV-1 and to suppress chronic hepatitis B.
Teplizumab is a humanised monoclonal antibody that changes the activity of T lymphocytes involved in autoimmune damage to insulin-producing cells. It is licensed to delay progression from Stage 2 to Stage 3 type 1 diabetes in eligible adults and children aged 8 years and older; it does not cure type 1 diabetes.
Tepotinib hydrochloride hydrate is a targeted protein kinase inhibitor for adults with advanced non-small cell lung cancer whose tumour has a confirmed MET exon 14 skipping alteration.
Teprotumumab is a monoclonal antibody that blocks the insulin-like growth factor-1 receptor. It is licensed for adults with moderate to severe thyroid eye disease and is given by intravenous infusion under specialist supervision.
Terazosin is a prescription-only alpha-1 blocker licensed in adults to lower blood pressure and relieve urinary obstruction symptoms caused by benign prostatic hyperplasia (BPH).
Terbinafine is an allylamine antifungal that kills susceptible fungi. The selected topical gel treats athlete’s foot, jock itch and ringworm affecting the skin.
Terbinafine hydrochloride is an allylamine antifungal for susceptible fungal infections of the skin or nails. Tablets and topical products have different licensed uses.
Terbutaline sulfate is a short-acting beta2 agonist that relaxes tightened airway muscle. It mainly relieves bronchospasm in asthma and other lung disorders; an injection also has a restricted obstetric indication.
Teriflunomide is an oral disease-modifying treatment that changes immune activity in multiple sclerosis. The selected UK product is licensed for relapsing-remitting multiple sclerosis in adults and children aged 10 years and over. It is not a cure or a treatment for an acute relapse.
Teriparatide is a prescription treatment related to human parathyroid hormone. It stimulates new bone formation and treats osteoporosis in adults at increased risk of fractures.
Terlipressin acetate is a synthetic vasopressin analogue that narrows blood vessels supplying the gut and reduces portal pressure. The selected product is used in hospital to treat bleeding oesophageal varices alongside urgent procedures and supportive care.
Testosterone is a naturally occurring androgen hormone. These gels replace testosterone in adults with male hypogonadism when deficiency has been confirmed by symptoms and blood tests.
An oily injection containing four testosterone esters that release testosterone over different periods. It is used for confirmed male hypogonadism and may support specialist masculinising hormone therapy.
Testosterone enantate is a long-acting injectable form of testosterone, licensed for replacement therapy in adult men with hypogonadism confirmed by clinical features and biochemical tests.
Testosterone undecanoate is a long-acting form of testosterone injected into a muscle. It replaces testosterone in men with confirmed hypogonadism, after symptoms and blood tests establish deficiency.
Tetrabenazine is a prescription-only VMAT2 inhibitor that reduces dopamine and other monoamines in the brain. It is used to lessen certain involuntary movements, including chorea and selected cases of persistent, disabling tardive dyskinesia.
Tetracaine is an ester-type local anaesthetic that temporarily numbs intact skin. The selected UK gel is used before venepuncture or insertion of a venous cannula in adults and infants over one month old.
Tetracaine hydrochloride is a local anaesthetic eye drop used by eye-care professionals to temporarily numb the eye’s surface during examinations or treatments.
Tetracosactide acetate is a synthetic part of adrenocorticotropic hormone (ACTH) that stimulates the adrenal glands to release corticosteroid hormones. It is used in adrenal function testing; the depot product is also licensed for short-term treatment of selected steroid-responsive inflammatory conditions.
Tetrofosmin is used to prepare a technetium-99m radioactive tracer for diagnostic imaging in adults. It mainly shows blood flow through heart muscle and can help assess certain suspected breast lesions when initial tests are inconclusive.
Theophylline hydrate is a xanthine bronchodilator that relaxes the airways. It is usually an add-on treatment to help prevent bronchospasm in asthma or chronic obstructive lung disease when other treatments are insufficient.
Thiamine hydrochloride is a medicinal form of thiamine (vitamin B1), an essential water-soluble vitamin. It replaces thiamine when levels are low; an injection may be used when rapid replacement is needed or oral treatment is unsuitable.
Tisotumab vedotin is an antibody–drug conjugate that delivers the cell-killing substance MMAE to cancer cells expressing tissue factor. It is used alone for adults with recurrent or metastatic cervical cancer that has progressed during or after previous systemic treatment.
Tofersen is an antisense oligonucleotide licensed for adults with amyotrophic lateral sclerosis caused by a confirmed SOD1 gene mutation. It reduces abnormal SOD1 protein production but is not a cure, and response varies.
Toripalimab helps immune cells recognise and attack cancer. In the UK, it is used with chemotherapy for certain advanced nasopharyngeal and oesophageal cancers.
Tramadol hydrochloride is a prescription opioid painkiller for moderate to severe pain. It changes how pain signals are processed in the brain and spinal cord but can cause sedation, dependence and withdrawal.