tedizolid phosphate at a glance
Medicine class
Oxazolidinone antibiotic
Licensed use
Acute bacterial skin and skin-structure infections
Available routes
Tablets or intravenous infusion; switching between routes may be possible when clinically appropriate
Food
Tablets may be swallowed whole with or without food
What is tedizolid phosphate used for?
Licensed uses represented by the selected products:
Treatment of acute bacterial skin and skin-structure infections in adults.
Treatment of acute bacterial skin and skin-structure infections in children and adolescents, using the formulation appropriate to body weight.
How does tedizolid phosphate work?
Tedizolid phosphate is a prodrug that is rapidly converted to tedizolid. Tedizolid binds to the bacterial ribosome’s 50S subunit and blocks protein production, stopping susceptible bacteria—mainly Gram-positive organisms—from multiplying.
tedizolid phosphate preparations and strengths
Solution for infusion
Route: Intravenous
Strengths: 200 mg
Tablet
Route: Oral
Strengths: 200 mg
How to take tedizolid phosphate
Follow the prescriber’s instructions. Swallow tablets whole, with or without food. The intravenous formulation is prepared and given through a vein by a healthcare professional; treatment may be changed from infusion to tablets when clinically appropriate.
Do not stop treatment without discussing it with the prescriber.
Do not drive or operate machinery if tedizolid phosphate makes you dizzy, tired or sleepy.
Tell the clinical team if the infection is worsening or not improving.
tedizolid phosphate side effects
Common or expected effects
- Nausea or vomiting
- Headache
- Diarrhoea
- Itching
- Tiredness or dizziness
- Pain or swelling at the infusion site
Get urgent medical advice
- Severe allergic reaction, including facial or throat swelling and breathing difficulty
- Persistent, severe or bloody diarrhoea, which may indicate antibiotic-associated colitis
- Possible serotonin syndrome: confusion, high temperature, agitation, overactive reflexes or poor coordination
- Unusual bleeding or bruising, which may indicate a low platelet count
- New visual disturbance, numbness, tingling or sharp limb pain
tedizolid phosphate in pregnancy
Human pregnancy data are unavailable, and developmental effects occurred in animal studies. Product information advises avoiding tedizolid phosphate during pregnancy as a precaution; the prescriber should assess whether another suitable antibiotic can be used.
tedizolid phosphate while breastfeeding
It is unknown whether tedizolid phosphate or its metabolites enter human milk, and a risk to the infant cannot be excluded. A prescriber should weigh the benefits of breastfeeding and treatment when deciding whether breastfeeding or tedizolid phosphate should be interrupted.
tedizolid phosphate interactions
Check the complete medicines list before treatment, including prescribed, over-the-counter and herbal products.
Serotonergic antidepressants and monoamine oxidase inhibitors
Combined use has been associated with serotonin syndrome; assess necessity and monitor for characteristic symptoms.
Opioids, including fentanyl
Serotonergic opioids may increase the risk of serotonin syndrome when used with tedizolid phosphate.
Common questions about tedizolid phosphate
Answers are fully visible for fast scanning and source review.
What infections does tedizolid phosphate treat?
It is licensed for acute bacterial infections of the skin and tissues beneath the skin caused by susceptible bacteria.
Is tedizolid phosphate the same as tedizolid?
Tedizolid phosphate is the prodrug. The body converts it to tedizolid, the form with antibacterial activity.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.