clobetasone butyrate + nystatin + oxytetracycline calcium at a glance
Medicine class
Topical corticosteroid combined with antibacterial and antifungal agents
Licensed role
Steroid-responsive inflammatory skin conditions complicated by, or at risk of, bacterial or candidal infection
Who may receive it
Licensed for adults, older people, children and infants
Form
A water-miscible cream particularly suited to moist or weeping skin
Fire safety
Keep treated fabrics away from smoking and naked flames because product residue makes them burn more easily
What is clobetasone butyrate + nystatin + oxytetracycline calcium used for?
Licensed for steroid-responsive skin conditions where candidal or bacterial infection is present, suspected or likely.
Atopic dermatitis
Nappy rash
Intertrigo affecting skin folds
Inflamed anogenital itching
Seborrhoeic dermatitis
How does clobetasone butyrate + nystatin + oxytetracycline calcium work?
Clobetasone butyrate reduces inflammation, redness, swelling and itching. Nystatin disrupts fungal cell membranes, while oxytetracycline inhibits protein production in susceptible bacteria.
How to take clobetasone butyrate + nystatin + oxytetracycline calcium
For use on the skin only.
Spread gently over the affected skin as directed.
Wash your hands afterwards unless the hands are being treated.
Allow the cream to absorb before applying an emollient.
Do not dilute or mix it with other creams or ointments.
Avoid the eyes; rinse well with water after accidental eye contact.
Only use an airtight dressing or apply beneath a nappy when specifically advised.
clobetasone butyrate + nystatin + oxytetracycline calcium side effects
Common or expected effects
- Brief burning or stinging after application
- Small widened surface blood vessels
Get urgent medical advice
- Facial, mouth or throat swelling, breathing difficulty or another severe allergic reaction
- New or spreading skin infection
- Severe or persistent diarrhoea with abdominal cramps
- Blurred vision or another new visual disturbance
- Features of excessive corticosteroid absorption, such as rounded face, central weight gain, reduced growth in children or adrenal suppression
- Marked redness, burning, peeling or oozing that spreads beyond the treated area after stopping
clobetasone butyrate + nystatin + oxytetracycline calcium in pregnancy
Topical corticosteroids are generally considered usable during pregnancy because systemic absorption is usually low. Evidence for this complete combination is limited, so the prescriber should confirm that the expected benefit outweighs potential fetal risk.
clobetasone butyrate + nystatin + oxytetracycline calcium while breastfeeding
Topical corticosteroids generally produce negligible maternal blood and milk concentrations, but safety data for this complete combination are limited. Discuss use with the prescriber, prevent the infant from touching treated skin and do not apply the cream to the breasts.
clobetasone butyrate + nystatin + oxytetracycline calcium interactions
Systemic interactions are unlikely with limited topical absorption, but absorption can increase through damaged, inflamed or occluded skin.
Ritonavir and other strong CYP3A4 inhibitors
They can reduce corticosteroid metabolism and increase the risk of systemic steroid effects if meaningful absorption occurs.
Itraconazole and other strong CYP3A4 inhibitors
They may increase systemic corticosteroid exposure and associated adverse effects.
Common questions about clobetasone butyrate + nystatin + oxytetracycline calcium
Answers are fully visible for fast scanning and source review.
Is this a steroid cream?
Yes. It contains a moderately potent topical corticosteroid together with an antibiotic and an antifungal.
Can it treat MRSA?
No. Skin infections caused by MRSA are specifically listed as unsuitable for treatment with this product.
Can it be used on the face?
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.