clobetasol propionate + neomycin + nystatin at a glance
Medicine class
Very potent topical corticosteroid with antibacterial and antifungal agents.
Important formulation difference
The cream contains arachis oil and must not be used with peanut or soya allergy; this excipient is not listed for the ointment.
Fire safety
Keep treated skin, clothing, bedding and dressings away from cigarettes and naked flames because contaminated fabric burns more easily.
What is clobetasol propionate + neomycin + nystatin used for?
Licensed uses are resistant inflammatory skin conditions where secondary infection is relevant.
Recalcitrant eczema with secondary bacterial or candidal infection present, suspected or likely.
Psoriasis, excluding widespread plaque psoriasis, with secondary bacterial or candidal infection present, suspected or likely.
Other resistant steroid-responsive skin conditions complicated by, or at risk of, secondary bacterial or candidal infection.
How does clobetasol propionate + neomycin + nystatin work?
Clobetasol reduces inflammation, redness and itching. Neomycin kills susceptible bacteria, while nystatin acts against Candida.
clobetasol propionate + neomycin + nystatin preparations and strengths
Cream
Route: Cutaneous
Strengths: 0.5 mg + 5 mg + 100000 units/g
Ointment
Route: Cutaneous
Strengths: 0.5 mg + 5 mg + 100000 units/g
How to take clobetasol propionate + neomycin + nystatin
Use only on the skin and follow the prescription label. Do not dilute or mix it with other creams or ointments.
Wash your hands before and after application unless treating your hands.
Apply gently to affected skin, avoiding the eyes and untreated skin.
Do not use an airtight dressing unless specifically instructed; it increases absorption and can encourage infection.
Keep treated fabric away from flames and smoking materials.
clobetasol propionate + neomycin + nystatin side effects
Common or expected effects
- Skin thinning
- Small surface blood vessels becoming more visible
Get urgent medical advice
- Severe allergic reaction, including anaphylaxis
- Worsening, swelling or spread of the skin condition
- Pus-filled psoriasis lesions
- Blurred vision or other new visual disturbance
- Excessive steroid absorption, with effects such as facial rounding, growth suppression in a child, high blood pressure or raised blood glucose
- Spreading redness, burning, itching, peeling or oozing after stopping, which may represent topical steroid withdrawal
clobetasol propionate + neomycin + nystatin in pregnancy
Evidence for the complete combination is limited. A prescriber should review whether all three components are needed and assess the extent of skin exposure.
clobetasol propionate + neomycin + nystatin while breastfeeding
Safety of the complete combination has not been established, and the product information does not recommend its use. Discuss an alternative with the prescriber.
clobetasol propionate + neomycin + nystatin interactions
Clinically important interactions are most likely when absorption through the skin is increased.
Strong CYP3A4 inhibitors, including ritonavir and itraconazole
They can reduce corticosteroid metabolism and increase systemic steroid exposure.
Systemic aminoglycoside antibiotics
Combined exposure with neomycin may increase kidney or hearing toxicity if appreciable skin absorption occurs.
Common questions about clobetasol propionate + neomycin + nystatin
Answers are fully visible for fast scanning and source review.
Is it a steroid?
It contains the very potent topical corticosteroid clobetasol, plus the antibiotic neomycin and antifungal nystatin.
Can it treat ringworm or thrush by itself?
No. It is not licensed for primary fungal infections; nystatin is included for secondary candidal infection complicating an inflammatory skin condition.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.