How can ritonavir or itraconazole affect exposure to the corticosteroid in Trimovate Cream?

Ritonavir or itraconazole can inhibit CYP3A4-mediated corticosteroid metabolism, increasing systemic exposure to the corticosteroid in Trimovate Cream; clinical relevance depends on corticosteroid dose, administration route and CYP3A4 inhibitor potency.