Answer
No human data are available on the fertility effects of Orkambi’s active ingredients, lumacaftor and ivacaftor; in male and female rats, lumacaftor had no effect on fertility or reproductive performance, whereas ivacaftor impaired both.
Sources for this answer
- Orkambi 200 mg/125 mg film coated tabletsVertex Pharmaceuticals (Europe) Limited · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 19Document updated
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