nonacog beta pegol at a glance
Medicine class
Long-acting recombinant factor IX replacement
Licensed use
Prevention and treatment of bleeding in haemophilia B
How it is given
Injected into a vein after mixing the powder with the supplied solvent
Home treatment
Self-injection or caregiver administration requires training from the haemophilia team
What is nonacog beta pegol used for?
Nonacog beta pegol is licensed for people of all ages with haemophilia B, an inherited deficiency of factor IX.
Preventing bleeding.
Treating bleeding that has occurred.
Managing bleeding around surgery or dental procedures under specialist supervision.
How does nonacog beta pegol work?
Haemophilia B reduces the amount or activity of factor IX needed for normal clot formation. Nonacog beta pegol replaces factor IX. When activated, its polyethylene-glycol-containing activation segment is removed, leaving activated factor IX to support thrombin and fibrin formation. Pegylation keeps the inactive replacement factor in circulation for longer.
nonacog beta pegol preparations and strengths
Injection
Route: Parenteral
Strengths: 500 units, 1000 units, 2000 units, 3000 units
How to take nonacog beta pegol
Use only as taught by the haemophilia team. Reconstitute the powder with the supplied histidine solvent, use an aseptic technique and inject the prepared solution into a vein. Check that the solution is clear and colourless to slightly yellow. Do not use it if cloudy, discoloured or containing particles, and do not mix it with other medicines or infusion solutions.
Wash your hands and prepare equipment in a clean area.
Record the product name and batch number for traceability.
Use the reconstituted solution promptly and follow pack instructions for storage and disposal.
nonacog beta pegol side effects
Common or expected effects
- Nausea
- Itching or rash
- Fatigue
- Pain, swelling, redness or rash at the injection site
Get urgent medical advice
- A severe allergic reaction, including breathing difficulty, facial or throat swelling, faintness or shock
- Development of factor IX inhibitors, which may show as bleeding that is not controlled as expected
- Possible blood-clot symptoms such as sudden breathlessness, chest pain or a painful swollen limb
nonacog beta pegol in pregnancy
Experience with factor IX replacement during pregnancy is limited, so nonacog beta pegol should be used only when clearly indicated by specialists. Pregnancy in someone with haemophilia B or carrier status should be planned and managed jointly by haemophilia and obstetric teams.
nonacog beta pegol while breastfeeding
There is little direct evidence about nonacog beta pegol during breastfeeding. The product information advises use only when clearly indicated, following an individual assessment by the haemophilia and maternity teams.
nonacog beta pegol interactions
No direct interactions between recombinant factor IX products and other medicines have been reported. However, medicines that impair clotting can worsen the underlying bleeding tendency, so new medicines should be checked with the haemophilia team.
Aspirin and non-steroidal anti-inflammatory medicines such as ibuprofen
These can increase bleeding risk and should not be taken unless the haemophilia team has specifically advised their use.
Common questions about nonacog beta pegol
Answers are fully visible for fast scanning and source review.
Is nonacog beta pegol a factor IX treatment?
Yes. It is a recombinant form of human factor IX modified with polyethylene glycol to remain in circulation longer.
What type of haemophilia does nonacog beta pegol treat?
It treats haemophilia B, which is caused by congenital factor IX deficiency.
Can children receive nonacog beta pegol?
Yes. Its licence covers all age groups, with treatment overseen by an experienced haemophilia team.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.