eftrenonacog alfa at a glance
Medicine class
Extended-acting recombinant coagulation factor IX replacement
Licensed use
Treatment and prevention of bleeding in haemophilia B
Who can use it
Licensed for all age groups
Administration
Injected into a vein after reconstitution; home administration requires training
What is eftrenonacog alfa used for?
It is licensed for people of any age with haemophilia B caused by congenital factor IX deficiency.
Treating bleeding episodes
Preventing bleeding
Supporting haemostasis around surgery
How does eftrenonacog alfa work?
Haemophilia B results from insufficient working factor IX. Eftrenonacog alfa temporarily replaces factor IX, helping the body form a stable clot. Its Fc component slows removal from the circulation through the body's natural Fc-receptor recycling pathway.
eftrenonacog alfa preparations and strengths
Injection
Route: Parenteral
Strengths: 250 units, 500 units, 1000 units, 2000 units, 3000 units
How to take eftrenonacog alfa
Treatment must be supervised by a clinician experienced in haemophilia. The powder is dissolved with the supplied solvent and injected into a vein. Patients or carers may administer it after suitable training.
Follow the preparation technique taught by the haemophilia team and wash your hands first.
Let refrigerated components reach room temperature naturally; do not apply external heat.
Gently swirl to dissolve the powder; do not shake.
Use only a clear to slightly opalescent, colourless solution without visible particles.
Do not mix it with other injectable medicines. Use the supplied infusion set.
Record the product name and batch number after each administration.
Use the reconstituted solution promptly and discard used equipment safely.
eftrenonacog alfa side effects
Common or expected effects
- Headache
- Mouth numbness or tingling
- Redness at the injection site
- Urinary obstruction causing flank pain and blood in the urine
- In previously untreated children, factor IX inhibitors or hypersensitivity have been reported as common
Get urgent medical advice
- Sudden severe allergic reaction or anaphylaxis
- Persistent or poorly controlled bleeding, which may indicate a factor IX inhibitor
- Possible blood-clot symptoms, including sudden breathlessness or unexplained painful limb swelling
eftrenonacog alfa in pregnancy
Experience during pregnancy is unavailable, and reproductive studies are limited. Eftrenonacog alfa should be used only when clearly indicated. Pregnancy in someone with haemophilia B or carrying its gene requires early planning with specialist haemophilia and obstetric teams.
eftrenonacog alfa while breastfeeding
It is unknown whether eftrenonacog alfa passes into human milk, and clinical experience during breastfeeding is unavailable. A specialist should assess whether treatment is clearly needed.
eftrenonacog alfa interactions
No interactions with other medicines have been reported, but formal interaction studies have not been performed. Tell the haemophilia team about prescribed, over-the-counter and complementary products.
Common questions about eftrenonacog alfa
Answers are fully visible for fast scanning and source review.
Can it be given at home?
Yes. A patient or carer may give the intravenous injection after appropriate training from the haemophilia team.
Can children use it?
Yes. It is licensed for all age groups, with treatment individualised and supervised by a specialist haemophilia service.
What if it does not control bleeding?
Contact the haemophilia team promptly. Reduced response may have several causes, including development of a factor IX inhibitor.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.