nonacog gamma at a glance
Medicine class
Recombinant blood coagulation factor IX
Licensed use
Treatment and prevention of bleeding in haemophilia B
How it is given
Injected into a vein after the powder is mixed with the supplied solvent
Home treatment
Patients or carers may administer it after suitable training
What is nonacog gamma used for?
Nonacog gamma is licensed for people of all ages with haemophilia B caused by congenital factor IX deficiency.
Treating bleeding episodes
Preventing bleeding
Supporting haemostasis around surgery or invasive procedures
How does nonacog gamma work?
Factor IX forms part of the clotting cascade. Nonacog gamma temporarily replaces deficient factor IX, allowing activated factor IX and factor VIII to activate factor X. This leads to thrombin and fibrin formation and helps produce a stable blood clot.
nonacog gamma preparations and strengths
Injection
Route: Parenteral
Strengths: 1000 units, 2000 units
How to take nonacog gamma
Nonacog gamma is given into a vein under a specialist haemophilia plan. Self-administration or administration by a carer requires appropriate training.
Mix the powder only with the solvent and reconstitution device supplied in the pack.
Use aseptic technique and a plastic luer-lock syringe.
Do not use the mixed solution if it is cloudy, discoloured or contains deposits.
Use the reconstituted solution immediately and do not refrigerate it.
Record the product name and batch number whenever possible.
nonacog gamma side effects
Common or expected effects
- Altered taste
- Pain in a limb
Get urgent medical advice
- Allergic or anaphylactic reaction, including breathing difficulty, wheezing, swelling, chest tightness, widespread hives, low blood pressure or collapse
- Reduced bleeding control caused by neutralising factor IX antibodies called inhibitors
- Possible thromboembolic complications, such as sudden chest pain, breathlessness or painful one-sided leg swelling
nonacog gamma in pregnancy
Evidence for factor IX use during pregnancy is limited. Nonacog gamma should be used only when clearly indicated, with planning by the haemophilia and maternity teams because inherited bleeding disorders require specialist multidisciplinary care during pregnancy and delivery.
nonacog gamma while breastfeeding
It is unknown whether factor IX passes into human milk. Use during breastfeeding should be considered with the prescriber and haemophilia team and only when clearly indicated.
nonacog gamma interactions
No interactions between recombinant factor IX products and other medicines have been reported. The haemophilia team should still be told about all medicines being used.
Other medicines
No medicine interactions are currently reported, but new or non-prescription treatments should still be discussed with the haemophilia team.
Medicines mixed in the same syringe or preparation
Do not mix with other medicines because compatibility has not been established.
Common questions about nonacog gamma
Answers are fully visible for fast scanning and source review.
Is nonacog gamma a clotting factor replacement?
Yes. It is recombinant human factor IX used to replace the factor IX missing or reduced in haemophilia B.
Does nonacog gamma come from donated human blood?
No. It is made using recombinant DNA technology in Chinese hamster ovary cells rather than being extracted from donated human blood.
Can children receive nonacog gamma?
Yes. Its UK licence covers people with haemophilia B in all age groups.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.