human coagulation factor II + human coagulation factor IX + human coagulation factor VII + human coagulation factor X + protein c + protein s at a glance
Medicine class
Human plasma-derived four-factor prothrombin complex concentrate.
Usual role
Rapid replacement of vitamin K-dependent clotting factors during serious bleeding or around urgent surgery.
Administration
Reconstituted and given into a vein under specialist supervision.
Important excipients
Contains heparin and sodium.
What is human coagulation factor II + human coagulation factor IX + human coagulation factor VII + human coagulation factor X + protein c + protein s used for?
UK-licensed uses include:
Treating bleeding or preventing bleeding around surgery when rapid correction of an acquired prothrombin-complex factor deficiency is needed, including deficiency caused by vitamin K antagonists or overdose.
Treating bleeding or preventing bleeding around surgery in congenital factor II or factor X deficiency when a purified specific-factor product is unavailable.
How does human coagulation factor II + human coagulation factor IX + human coagulation factor VII + human coagulation factor X + protein c + protein s work?
Factors VII, IX and X help activate coagulation, while factor II is converted to thrombin, supporting formation of a fibrin clot. The infusion temporarily raises deficient factor levels. Proteins C and S are natural regulators of coagulation.
How to take human coagulation factor II + human coagulation factor IX + human coagulation factor VII + human coagulation factor X + protein c + protein s
This hospital-based intravenous treatment is supervised by a clinician experienced in coagulation disorders. The powder is reconstituted with the supplied water for injections using aseptic technique. It must not be used if cloudy, discoloured or containing deposits, or mixed with other medicinal products.
Pulse should be checked before and during administration.
The product name and batch number should be recorded for traceability.
The reconstituted solution is normally used immediately.
human coagulation factor II + human coagulation factor IX + human coagulation factor VII + human coagulation factor X + protein c + protein s side effects
Common or expected effects
- Blood clots in deep veins have been reported as common in clinical-trial data.
Get urgent medical advice
- Severe allergic or anaphylactic reactions, including breathing difficulty, low blood pressure or collapse.
- Blood clots, including pulmonary embolism, or disseminated intravascular coagulation.
- A sudden heparin-related fall in platelets, particularly after previous heparin-induced thrombocytopenia.
- Poor response caused by antibodies that inhibit one or more replacement factors.
human coagulation factor II + human coagulation factor IX + human coagulation factor VII + human coagulation factor X + protein c + protein s in pregnancy
Safety during pregnancy has not been established. Use only when clearly indicated after specialist assessment of bleeding and treatment risks. Clinicians should also consider viral-safety information, including the particular relevance of parvovirus B19 during pregnancy.
human coagulation factor II + human coagulation factor IX + human coagulation factor VII + human coagulation factor X + protein c + protein s while breastfeeding
Safety during breastfeeding has not been established. Use is reserved for situations where the treating specialist considers it clearly indicated.
human coagulation factor II + human coagulation factor IX + human coagulation factor VII + human coagulation factor X + protein c + protein s interactions
Few interactions are established, but the intended anticoagulant-reversal effect is clinically important.
Vitamin K antagonists, including warfarin
The concentrate neutralises their anticoagulant effect by replacing vitamin K-dependent clotting factors.
Common questions about human coagulation factor II + human coagulation factor IX + human coagulation factor VII + human coagulation factor X + protein c + protein s
Answers are fully visible for fast scanning and source review.
Is Octaplex the same as vitamin K?
No. Octaplex directly replaces deficient clotting factors for rapid correction, whereas vitamin K enables the body to make new vitamin K-dependent factors.
Why is Octaplex given to someone taking warfarin?
It can rapidly reverse warfarin's anticoagulant effect when major bleeding or emergency surgery requires urgent correction.
Is Octaplex made from human blood?
Yes. It is manufactured from pooled human plasma using donor screening, testing and viral inactivation or removal measures, although infection transmission cannot be completely excluded.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.