factor IX at a glance
Medicine class
Human coagulation factor replacement
Main use
Preventing and treating bleeding in haemophilia B
Administration
Injected into a vein after the powder has been dissolved
Source
Replenine-VF is made from donated human plasma
What is factor IX used for?
Replenine-VF is licensed for:
Treating bleeding in people with haemophilia B.
Preventing bleeding in people with haemophilia B, including around surgery or procedures.
How does factor IX work?
Factor IX participates in the clotting cascade. Replacement temporarily raises circulating factor IX so clot formation can proceed more effectively.
factor IX preparations and strengths
Injection
Route: Parenteral
Strengths: 50 units/mL
How to take factor IX
Use under the supervision of a clinician experienced in haemophilia. Replenine-VF is dissolved using the supplied water and equipment, then injected into a vein by a trained person.
Bring the vials to the stated room temperature before reconstitution.
Gently swirl; do not shake.
Use only if the solution is clear or slightly opalescent, without deposits or particles.
Use the reconstituted solution within the permitted in-use period.
Do not mix it with other medicines or use unapproved injection equipment.
factor IX side effects
Common or expected effects
- Headache
- Injection-site irritation or inflammation
Get urgent medical advice
- Severe allergic reaction or anaphylaxis
- Factor IX inhibitors, which may make treatment less effective
- Rare blood-clotting complications
- Kidney problems, particularly during immune-tolerance treatment in people with inhibitors and previous allergic reactions
factor IX in pregnancy
Experience during pregnancy is limited. Factor IX should be used only when clearly indicated, following advice from haemophilia and maternity specialists.
factor IX while breastfeeding
Experience during breastfeeding is limited. Use should be based on specialist assessment; discuss breastfeeding with the prescriber or haemophilia team.
factor IX interactions
No interactions between human coagulation factor IX products and other medicines have been reported. Tell the haemophilia team about all prescribed, non-prescribed and complementary products.
Common questions about factor IX
Answers are fully visible for fast scanning and source review.
Is factor IX the same as factor VIII?
No. Factor IX deficiency causes haemophilia B, while factor VIII deficiency causes haemophilia A.
Can factor IX be administered at home?
Many patients or carers can give intravenous clotting factor at home after training and with support from their haemophilia centre.
What if factor IX does not stop a bleed?
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.