How can ritonavir or itraconazole affect corticosteroid exposure when used with clobetasol propionate + neomycin + nystatin cream?

With clobetasol propionate + neomycin + nystatin cream, ritonavir or itraconazole can inhibit CYP3A4-mediated corticosteroid metabolism, increasing systemic exposure; clinical relevance depends on corticosteroid dose and administration route and CYP3A4 inhibitor potency.