calcium chloride dihydrate + glucose, anhydrous + glucose monohydrate + magnesium chloride hexahydrate + sodium chloride + sodium hydrogen carbonate + sodium lactate at a glance
Class
Hypertonic peritoneal dialysis solution
Route
Into the peritoneal cavity through a dialysis catheter; never into a vein
Presentation
Sterile, clear solution in a two-chamber bag that must be mixed before use
Safety check
Do not use a leaking, damaged, cloudy or particle-containing bag
What is calcium chloride dihydrate + glucose, anhydrous + glucose monohydrate + magnesium chloride hexahydrate + sodium chloride + sodium hydrogen carbonate + sodium lactate used for?
Licensed uses when peritoneal dialysis is employed include:
Acute or chronic kidney failure
Severe fluid retention
Severe electrolyte imbalance
Poisoning with a dialysable substance when a more suitable alternative is unavailable
Use in people with abdominal inflow pain or discomfort from low-pH, lactate-only dialysis solutions
How does calcium chloride dihydrate + glucose, anhydrous + glucose monohydrate + magnesium chloride hexahydrate + sodium chloride + sodium hydrogen carbonate + sodium lactate work?
The abdominal lining acts as a filter. Waste diffuses from the blood into the dialysis fluid, while glucose draws excess water across the membrane. The electrolytes, bicarbonate and lactate support electrolyte and acid–base regulation; lactate is converted to bicarbonate.
How to take calcium chloride dihydrate + glucose, anhydrous + glucose monohydrate + magnesium chloride hexahydrate + sodium chloride + sodium hydrogen carbonate + sodium lactate
Use only through the intraperitoneal route after training by a specialist dialysis team. Follow the taught aseptic exchange procedure and prescribed dialysis plan.
Mix both chambers fully before connection. If unmixed solution enters the abdomen, drain it and contact the dialysis team.
Discard the bag if it is damaged, leaking, discoloured, cloudy or contains particles.
If warming is advised, use dry heat only. Do not use hot water or a microwave.
Check drained fluid for cloudiness or fibrin and report abnormalities promptly.
Each bag is for single use and must be used within its stated in-use period after mixing.
calcium chloride dihydrate + glucose, anhydrous + glucose monohydrate + magnesium chloride hexahydrate + sodium chloride + sodium hydrogen carbonate + sodium lactate side effects
Common or expected effects
- Fluid retention, swelling or weight gain
- Low blood potassium or high blood calcium
- High blood pressure
- Weakness or tiredness
Get urgent medical advice
- Cloudy drained fluid, abdominal pain, fever or vomiting: possible peritonitis
- Facial or throat swelling, severe rash or breathing difficulty: possible hypersensitivity
- Severe breathlessness or marked abdominal swelling: possible overfilling or fluid overload
- Severe dizziness, faintness or sudden weight loss: possible excessive fluid removal
- Persistent abdominal symptoms, poor drainage or loss of dialysis effectiveness: possible serious peritoneal complication
calcium chloride dihydrate + glucose, anhydrous + glucose monohydrate + magnesium chloride hexahydrate + sodium chloride + sodium hydrogen carbonate + sodium lactate in pregnancy
Product-specific pregnancy data are limited, and the UK product information does not recommend this solution during pregnancy. Pregnancy during dialysis requires early review and close joint care from renal and specialist obstetric teams.
calcium chloride dihydrate + glucose, anhydrous + glucose monohydrate + magnesium chloride hexahydrate + sodium chloride + sodium hydrogen carbonate + sodium lactate while breastfeeding
It is unknown whether relevant metabolites enter human milk, and risk to a breastfed infant cannot be excluded. Renal and maternity teams should weigh the benefits of breastfeeding against the need for this solution.
calcium chloride dihydrate + glucose, anhydrous + glucose monohydrate + magnesium chloride hexahydrate + sodium chloride + sodium hydrogen carbonate + sodium lactate interactions
Formal interaction studies have not been performed. Important considerations include:
Dialysable medicines
Peritoneal dialysis may lower their blood concentrations, requiring specialist review and monitoring.
Cardiac glycosides, including digoxin
Potassium changes can increase toxicity risk; potassium and clinical response require careful monitoring.
Insulin and other glucose-lowering treatments
Glucose absorption can raise blood glucose, so diabetes treatment may need specialist adjustment.
Common questions about calcium chloride dihydrate + glucose, anhydrous + glucose monohydrate + magnesium chloride hexahydrate + sodium chloride + sodium hydrogen carbonate + sodium lactate
Answers are fully visible for fast scanning and source review.
Can it be given into a vein?
No. It is only for administration into the peritoneal cavity through a dialysis catheter.
Why does the bag have two chambers?
The glucose/electrolyte solution and bicarbonate/lactate buffer are stored separately and mixed before use.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.