calcium chloride + icodextrin + magnesium chloride + sodium chloride + sodium lactate at a glance
Medicine class
Icodextrin-based peritoneal dialysis solution and osmotic agent.
Usual role
Used within continuous ambulatory or automated peritoneal dialysis, particularly when glucose solutions no longer remove enough fluid.
Administration
Placed into the peritoneal cavity through a dialysis catheter; never injected into a vein.
What is calcium chloride + icodextrin + magnesium chloride + sodium chloride + sodium lactate used for?
Licensed as part of peritoneal dialysis for chronic renal failure.
Replacement for a glucose-based exchange within continuous ambulatory peritoneal dialysis.
Replacement for a glucose-based exchange within automated peritoneal dialysis.
Particularly useful when ultrafiltration with glucose-based solutions has declined.
How does calcium chloride + icodextrin + magnesium chloride + sodium chloride + sodium lactate work?
Icodextrin is a starch-derived glucose polymer. It creates a sustained osmotic gradient across the peritoneal membrane, drawing water from the blood into the dialysis fluid. Waste substances also cross into the fluid and leave when it is drained. Amylase breaks icodextrin into smaller carbohydrates, including maltose.
How to take calcium chloride + icodextrin + magnesium chloride + sodium chloride + sodium lactate
Use intraperitoneally exactly as prescribed and taught by the specialist dialysis team. It is not swallowed, so food does not affect administration.
Use aseptic technique for every connection and exchange.
Check that the bag and seals are intact and the solution is clear, colourless and particle-free. Do not use an abnormal, damaged or leaking bag.
If warming is advised, keep the bag in its overpouch and use dry heat only. Never use water or a microwave.
Inspect drained fluid for cloudiness or fibrin. Keep an abnormal drained bag and its batch details for the dialysis team.
Each bag is for single use.
calcium chloride + icodextrin + magnesium chloride + sodium chloride + sodium lactate side effects
Common or expected effects
- Abdominal pain
- Rash, itching or peeling skin
- Dehydration or reduced circulating fluid volume
- Dizziness or headache
- Low or high blood pressure
- Peripheral swelling
- Weakness
- Tinnitus
Get urgent medical advice
- Cloudy drained fluid, abdominal pain, fever or systemic illness suggesting peritonitis
- Facial or throat swelling, bronchospasm, collapse or another severe hypersensitivity reaction
- Widespread blistering, peeling or target-like skin lesions
- Severe dehydration with faintness, confusion or neurological symptoms
- Breathlessness, marked abdominal distension or fullness associated with overfilling
- Severe or unrecognised hypoglycaemia caused by an incompatible glucose-testing system
calcium chloride + icodextrin + magnesium chloride + sodium chloride + sodium lactate in pregnancy
Pregnancy data are absent or limited. The UK product information does not recommend use during pregnancy or in someone who could become pregnant and is not using contraception. Discuss pregnancy or plans for pregnancy promptly with the renal and obstetric teams.
calcium chloride + icodextrin + magnesium chloride + sodium chloride + sodium lactate while breastfeeding
It is unknown whether icodextrin metabolites pass into human milk, and risk to the infant cannot be excluded. The specialist team should weigh the importance of treatment against the benefits of breastfeeding and consider suitable alternatives where available.
calcium chloride + icodextrin + magnesium chloride + sodium chloride + sodium lactate interactions
Formal interaction studies have not been performed. Important practical interactions arise from dialysis, maltose formation and the lactate-containing formulation.
Non-glucose-specific blood glucose meters and test strips
GDH-PQQ, GDO and some GDH-FAD systems may report falsely high glucose, risking excessive insulin or missed hypoglycaemia.
Insulin
Changing from glucose-based dialysis fluid can alter insulin requirements, requiring specialist review of glucose control and insulin therapy.
Dialysable medicines
Common questions about calcium chloride + icodextrin + magnesium chloride + sodium chloride + sodium lactate
Answers are fully visible for fast scanning and source review.
Why can icodextrin affect blood glucose meters?
It is partly broken down into maltose, which some meter and strip methods mistake for glucose, producing a falsely high result.
Can glucose-meter interference continue after treatment stops?
Yes. Incompatible systems may give false high readings for up to two weeks afterwards, so glucose-specific testing remains essential during that period.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.