Answer
Ketoconazole may increase systemic exposure to tapentadol hydrochloride by strongly inhibiting UGT enzymes involved in tapentadol's major elimination pathway, conjugation with glucuronic acid.
Sources for this answer
- Palexia SR 250 mg prolonged-release tabletsGrunenthal Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 10Document updated
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