Answer
Tapentadol hydrochloride relieves pain by activating µ-opioid receptors and inhibiting noradrenaline reuptake, acting directly without a pharmacologically active metabolite.
Sources for this answer
- Palexia SR 250 mg prolonged-release tabletsGrunenthal Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 10Document updated
Sources checked