Why should Palexia SR (tapentadol hydrochloride) be avoided during or within 14 days of taking monoamine oxidase inhibitors?

Palexia SR (tapentadol hydrochloride) should be avoided during or within 14 days of taking monoamine oxidase inhibitors because additive effects on synaptic noradrenaline concentrations may cause adverse cardiovascular events, including hypertensive crisis.