Answer
Hepatitis B screening is recommended for all patients before starting sofosbuvir + velpatasvir because HBV reactivation, sometimes fatal, has occurred during or after direct-acting antiviral treatment, and patients with HBV/HCV co-infection require monitoring and management.
Sources for this answer
- Sofosbuvir/Velpatasvir Gilead 400 mg/100 mg film coated tablets.Gilead Sciences Ltd · emc · SmPC §4.4 Special warnings and precautions for use · Version 22Document updated
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