Answer
Sofosbuvir + velpatasvir may increase digoxin concentrations through P-gp inhibition, so caution and therapeutic concentration monitoring of digoxin are recommended; the interaction was studied only with velpatasvir.
Sources for this answer
- Sofosbuvir/Velpatasvir Gilead 400 mg/100 mg film coated tablets.Gilead Sciences Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 22Document updated
Sources checked