Answer
During sofosbuvir + velpatasvir treatment, acid-reducing medicines that increase gastric pH are expected to lower velpatasvir concentrations because velpatasvir becomes less soluble as pH increases.
Sources for this answer
- Sofosbuvir/Velpatasvir Gilead 400 mg/100 mg film coated tablets.Gilead Sciences Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 22Document updated
Sources checked