Answer
The combination can raise liver enzymes and has been associated with serious liver complications, particularly in advanced pre-existing liver disease.
Sources for this answer
- Orkambi 150 mg/188 mg granules in sachet — Current selected SmPCemc · Summary of Product Characteristics
- Orkambi 200 mg/125 mg film coated tablets — Current selected SmPCemc · Summary of Product Characteristics
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