Answer
Yes. It can reduce the effectiveness of hormonal pills, injections, patches and implants, which should not be relied upon as effective contraception during treatment.
Sources for this answer
- Orkambi 150 mg/188 mg granules in sachetemc · SmPC Current selected SmPC · Version 10
- Orkambi 200 mg/125 mg film coated tabletsemc · SmPC Current selected SmPC · Version 19