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Medicines tacrolimusQuestion & answer

tacrolimus · Medicine question

Which enzymes primarily metabolise tacrolimus in the liver?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Tacrolimus is primarily metabolised in the liver by cytochrome P450-3A4 (CYP3A4) and cytochrome P450-3A5 (CYP3A5).

Sources for this answer

Prograf 5mg/ml Concentrate for Solution for Infusion (UK)Astellas Pharma Ltd · emc · SmPC §5.2 Pharmacokinetic properties · Version 29Document updated 17 March 2026

Sources checked 8 November 2026

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tacrolimus

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