Answer
Cannabidiol has been reported to increase tacrolimus blood levels during concomitant use, possibly by inhibiting intestinal P-glycoprotein and increasing tacrolimus bioavailability; co-administration requires caution, close monitoring for side effects and tacrolimus whole-blood trough concentrations, and tacrolimus dose adjustment if needed.
Sources for this answer
- Prograf 5mg/ml Concentrate for Solution for Infusion (UK)Astellas Pharma Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 29Document updated
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