Answer
Clarithromycin, a strong CYP3A4 inhibitor, may increase tacrolimus blood levels, risking nephrotoxicity, neurotoxicity and QT prolongation; concurrent use should be avoided or, if unavoidable, managed with frequent tacrolimus-level monitoring and possible dose adjustment under a transplant specialist.
Sources for this answer
- Prograf 5mg/ml Concentrate for Solution for Infusion (UK)Astellas Pharma Ltd · emc · SmPC §4.4 Special warnings and precautions for use · Version 29Document updated
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