Answer
Baseline neutrophils below 1.5 × 10⁹/l and/or a platelet count below 100 × 10⁹/l indicate severe bone marrow depression that contraindicates intravenous topotecan hydrochloride before the first course.
Sources for this answer
- Topotecan Hospira 4 mg/4 ml concentrate for solution for infusionPfizer Limited · emc · SmPC §4.3 Contraindications · Version 18Document updated
Sources checked