Answer
Topotecan hydrochloride inhibits topoisomerase I by stabilising the covalent complex between the enzyme and strand-cleaved DNA, inducing protein-associated DNA single-strand breaks.
Sources for this answer
- Topotecan Hospira 4 mg/4 ml concentrate for solution for infusionPfizer Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 18Document updated
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