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Medicines ivacaftor + lumacaftorQuestion & answer

ivacaftor + lumacaftor · Medicine question

What is the contraindication to taking Orkambi?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Orkambi is contraindicated in people with hypersensitivity to its active substances, lumacaftor or ivacaftor, or any excipient listed in section 6.1.

Sources for this answer

Orkambi 200 mg/125 mg film coated tabletsVertex Pharmaceuticals (Europe) Limited · emc · SmPC §4.3 Contraindications · Version 19Document updated 12 December 2025

Sources checked 8 November 2026

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ivacaftor + lumacaftor

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