ipratropium bromide + xylometazoline hydrochloride at a glance
Medicine class
Topical sympathomimetic decongestant plus anticholinergic
Licensed role
Relief of blocked and runny nose caused by a common cold in adults
Administration
For nasal use; clear the nose first, keep the bottle upright and breathe in gently while spraying
Important precaution
Avoid the eyes and do not share the bottle
What is ipratropium bromide + xylometazoline hydrochloride used for?
This product is licensed for symptomatic treatment in adults.
Nasal congestion together with a runny nose caused by a common cold.
It is not licensed for allergy, sinusitis without a cold or people under 18 years.
How does ipratropium bromide + xylometazoline hydrochloride work?
Xylometazoline narrows blood vessels in the nasal lining, reducing swelling. Ipratropium blocks muscarinic signalling in nasal glands, reducing watery secretions.
ipratropium bromide + xylometazoline hydrochloride preparations and strengths
Nasal preparation
Route: Nasal
Strengths: 0.5 mg/mL + 0.6 mg/mL
How to take ipratropium bromide + xylometazoline hydrochloride
Use only in the nose and follow the pump-specific leaflet supplied with the bottle.
Clear the nose and keep the bottle upright.
Insert the nozzle, operate the pump and breathe in gently through the nose.
Clean and dry the nozzle after use, then replace the cap.
Prime or re-prime only as directed for the supplied pump.
Do not repeat an application if a full spray was not delivered.
Avoid the eyes. If contact occurs, rinse thoroughly with cold water.
Only one person should use each bottle.
ipratropium bromide + xylometazoline hydrochloride side effects
Common or expected effects
- Nosebleed
- Nasal dryness, discomfort or burning
- Headache or dizziness
- Dry mouth or throat irritation
- Altered taste
- Nausea
Get urgent medical advice
- Severe allergic reaction, including facial or throat swelling, breathing difficulty or anaphylaxis
- Eye pain, blurred or halo vision, a red eye or increased eye pressure
- Marked palpitations, fast or irregular heartbeat
- Difficulty passing urine
- Bronchospasm, throat swelling or laryngospasm
ipratropium bromide + xylometazoline hydrochloride in pregnancy
Use during pregnancy is not advised because evidence for the combination is insufficient and xylometazoline can cause systemic vasoconstriction. Ask a pharmacist, midwife or prescriber about alternatives.
ipratropium bromide + xylometazoline hydrochloride while breastfeeding
It is not known whether either active ingredient passes into breast milk in clinically relevant amounts. Use while breastfeeding should be considered only after medical advice and an assessment of benefit and potential infant risk.
ipratropium bromide + xylometazoline hydrochloride interactions
Check current and recently stopped medicines with a pharmacist or prescriber before use.
Monoamine oxidase inhibitors
Combining these with xylometazoline, including shortly after stopping treatment, may cause a dangerous rise in blood pressure.
Tricyclic or tetracyclic antidepressants
The sympathomimetic effect may be enhanced, with a risk of substantially raised blood pressure.
Other oral or nasal decongestants
Concurrent use can increase adverse effects and should be avoided.
Common questions about ipratropium bromide + xylometazoline hydrochloride
Answers are fully visible for fast scanning and source review.
What is it used for?
It relieves a blocked and runny nose associated with a common cold in adults.
Can children use it?
No. This product is contraindicated below 18 years.
Can it make congestion worse?
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.