Answer
The product information advises avoiding Otrivine Extra Dual Relief nasal spray during pregnancy because pregnancy data and reproductive-toxicity studies are insufficient, xylometazoline may cause systemic vasoconstriction, and ipratropium’s clinical safety in human pregnancy has not been established.
Sources for this answer
- Otrivine Extra Dual Relief 0.5 mg/ml + 0.6 mg/ml nasal spray, solutionHaleon Dungarvan · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 7Document updated
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