human coagulation factor X at a glance
Medicine class
Plasma-derived coagulation-factor replacement
Licensed uses
Treating and preventing bleeding, including around surgery, in hereditary factor X deficiency
How it is given
Injection into a vein after the powder has been reconstituted
Home treatment
Possible after appropriate training, with regular specialist review
What is human coagulation factor X used for?
Human coagulation factor X is licensed for people of any age with hereditary factor X deficiency.
Treatment of bleeding episodes
Prevention of bleeding episodes
Management of bleeding risk before, during and after surgery
How does human coagulation factor X work?
Factor X has a key role in the clotting cascade. Once activated to factor Xa, it helps generate thrombin, which converts fibrinogen into the fibrin mesh that stabilises a blood clot. Replacement temporarily restores this missing step.
human coagulation factor X preparations and strengths
Injection
Route: Parenteral
Strengths: 250 units, 500 units
How to take human coagulation factor X
It is given into a vein. Reconstitute the powder only with the supplied water and transfer device; gently swirl rather than shake. Use only a clear, colourless or slightly opalescent solution without particles or deposits. Home administration requires specialist training.
Bring the vials to room temperature without heating above the stated storage limit.
Use the reconstituted solution immediately where possible.
Do not mix it with another medicine in the same preparation.
Record the product name and batch number for traceability.
human coagulation factor X side effects
Common or expected effects
- Pain or redness at the infusion site
- Tiredness
- Back pain
Get urgent medical advice
- Severe allergic reaction, including breathing difficulty, facial or throat swelling, widespread hives, marked dizziness or shock
- Possible neutralising antibodies if factor X levels do not rise or bleeding is not controlled as expected
- Possible thrombosis following excessive administration
human coagulation factor X in pregnancy
Experience during pregnancy is very limited, so specialists should use it only when clearly indicated. Factor X deficiency increases bleeding risks around miscarriage, procedures and childbirth; plan pregnancy and delivery with specialist haematology and maternity teams.
human coagulation factor X while breastfeeding
There is little direct experience during breastfeeding. The prescriber and specialist haemophilia team should consider use only when clearly indicated.
human coagulation factor X interactions
Tell the haemophilia team about all anticoagulants and other medicines before treatment.
Direct or indirect factor Xa inhibitors
These anticoagulants oppose replacement factor X and should not be used in people with factor X deficiency without specialist management.
Common questions about human coagulation factor X
Answers are fully visible for fast scanning and source review.
What is human coagulation factor X used for?
It treats or prevents bleeding, including bleeding associated with surgery, in people with inherited factor X deficiency.
Is it made from blood plasma?
Yes. The licensed product is purified from donated human plasma and undergoes donor screening and pathogen-reduction processes, although infection risk cannot be eliminated completely.
Does it cure factor X deficiency?
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.