dextromethorphan hydrobromide + pseudoephedrine hydrochloride + triprolidine hydrochloride at a glance
Medicine class
Antitussive, sympathomimetic decongestant and sedating H1 antihistamine.
Usual role
Relief of dry cough with nasal congestion, sneezing, runny nose or watery eyes.
Age restriction
For adults and children aged 12 years and over; contraindicated below 12 years.
Driving and alcohol
It may cause drowsiness or impaired concentration. Avoid alcohol and do not drive or use machinery if affected.
What is dextromethorphan hydrobromide + pseudoephedrine hydrochloride + triprolidine hydrochloride used for?
The selected product is licensed for symptoms that benefit from all three components.
Suppressing a dry, irritating cough.
Relieving a blocked or stuffy nose.
Relieving associated sneezing, runny nose and watery eyes.
How does dextromethorphan hydrobromide + pseudoephedrine hydrochloride + triprolidine hydrochloride work?
Dextromethorphan reduces activity in the brain’s cough centre. Pseudoephedrine constricts swollen nasal blood vessels, easing congestion. Triprolidine blocks histamine H1 receptors, reducing sneezing and a runny nose, but can cause drowsiness.
How to take dextromethorphan hydrobromide + pseudoephedrine hydrochloride + triprolidine hydrochloride
Use only by mouth and follow the product label. Shake the bottle thoroughly and measure the liquid with the supplied spoon without overfilling it.
Do not combine it with another cough, cold or decongestant product.
Avoid alcoholic drinks.
Do not use it to make a child sleepy.
Seek advice if symptoms persist or worsen.
dextromethorphan hydrobromide + pseudoephedrine hydrochloride + triprolidine hydrochloride side effects
Common or expected effects
- Headache
- Difficulty sleeping or nervousness
- Dizziness or drowsiness
- Reduced concentration or difficulty performing tasks
- Blurred vision
- Dry mouth or thickened mucus
- Nausea or stomach upset
Get urgent medical advice
- Swelling of the face, lips, tongue or throat, breathing difficulty or a severe allergic rash
- Chest pain or other symptoms of reduced blood flow to the heart
- Sudden severe headache, confusion, seizure or visual disturbance
- Fever with widespread redness and numerous small pustules
- Sudden abdominal pain or rectal bleeding
- Hallucinations, severe agitation or features of serotonin syndrome
- Slow or shallow breathing
dextromethorphan hydrobromide + pseudoephedrine hydrochloride + triprolidine hydrochloride in pregnancy
Do not self-select this combination during pregnancy. Product information advises use only when the expected maternal benefit outweighs possible fetal risk, while pseudoephedrine is not recommended because it may reduce placental blood flow. Ask a doctor or pharmacist about alternatives.
dextromethorphan hydrobromide + pseudoephedrine hydrochloride + triprolidine hydrochloride while breastfeeding
This combination is not usually recommended while breastfeeding. Pseudoephedrine enters milk in small amounts and may reduce milk production; triprolidine also enters milk, and evidence for the complete combination is limited. Discuss alternatives with a pharmacist or prescriber, particularly for a newborn, premature or unwell infant.
dextromethorphan hydrobromide + pseudoephedrine hydrochloride + triprolidine hydrochloride interactions
Check prescribed, non-prescribed and recreational substances before use because important cardiovascular, sedative and serotonergic interactions can occur.
Monoamine oxidase inhibitors, including moclobemide
Concurrent or recent use can cause hypertensive crisis and serotonin syndrome and is contraindicated.
Selective serotonin reuptake inhibitors
Concurrent use is contraindicated because dextromethorphan can contribute to serotonin syndrome.
Other decongestants or sympathomimetics
Combining them can increase blood pressure, heart rate and other sympathomimetic adverse effects.
Common questions about dextromethorphan hydrobromide + pseudoephedrine hydrochloride + triprolidine hydrochloride
Answers are fully visible for fast scanning and source review.
What is it used for?
It relieves a dry cough with nasal congestion and associated sneezing, runny nose or watery eyes.
Is it suitable for a chesty cough?
It is intended for a dry cough. A cough producing substantial mucus should be assessed because suppressing it may be inappropriate.
Can children take it?
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.