dextromethorphan hydrobromide + pseudoephedrine hydrochloride + triprolidine hydrochloride · Medicine question

How does quinidine affect dextromethorphan concentrations when taken with Multi-Action ACTIFED Dry Coughs?

iatroX medicinesPublished 8 November 2026

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Quinidine inhibits CYP2D6 and can increase plasma dextromethorphan concentrations up to 20-fold when taken with Multi-Action ACTIFED Dry Coughs, increasing central nervous system adverse effects.

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Multi-Action ACTIFED Dry CoughsMcNeil Products Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 20Document updated 2 February 2026

Sources checked 8 November 2026

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