pseudoephedrine hydrochloride + triprolidine hydrochloride at a glance
Medicine class
Sympathomimetic decongestant plus sedating H1 antihistamine
Licensed uses
Symptomatic relief of allergic or vasomotor rhinitis, the common cold and influenza when both effects are useful
Administration
Oral tablet; swallow with water, with or without food
Alertness
May cause drowsiness; avoid alcohol and do not drive or operate machinery if affected
What is pseudoephedrine hydrochloride + triprolidine hydrochloride used for?
The selected tablet is licensed for symptomatic upper-respiratory disorders that benefit from both nasal decongestion and histamine H1-receptor blockade.
Allergic rhinitis
Vasomotor rhinitis
The common cold
Influenza
How does pseudoephedrine hydrochloride + triprolidine hydrochloride work?
Pseudoephedrine narrows swollen blood vessels in the nasal lining to reduce congestion. Triprolidine blocks histamine H1 receptors, helping relieve sneezing, runny nose and watery eyes; it can cause drowsiness.
How to take pseudoephedrine hydrochloride + triprolidine hydrochloride
Use by mouth exactly as directed on the product leaflet. Swallow the tablet with water; it can be taken with or without food.
Do not use more than one decongestant at the same time.
Avoid alcohol.
Do not drive or operate machinery until you know how the combination affects you.
Ask a pharmacist if symptoms persist, worsen or the instructions are unclear.
pseudoephedrine hydrochloride + triprolidine hydrochloride side effects
Common or expected effects
- Headache
- Drowsiness or impaired concentration
- Dizziness
- Nervousness, restlessness or difficulty sleeping
- Blurred vision
- Dry mouth or throat
- Nausea or abdominal discomfort
- Difficulty passing urine, particularly with prostate enlargement
Get urgent medical advice
- Sudden severe headache, confusion, seizure, vomiting or visual disturbance
- Fast, irregular or persistent pounding heartbeat, chest pain or stroke symptoms
- Sudden loss or marked reduction of vision
- Sudden abdominal pain or rectal bleeding
- Fever with widespread red skin and numerous small pustules
- Swelling of the face or throat, wheezing or difficulty breathing
pseudoephedrine hydrochloride + triprolidine hydrochloride in pregnancy
Pseudoephedrine is not recommended during pregnancy because it may reduce placental blood flow, and evidence concerning early-pregnancy exposure remains limited. There are no adequate controlled studies of this combination; obtain advice from a doctor or pharmacist before use.
pseudoephedrine hydrochloride + triprolidine hydrochloride while breastfeeding
This combination is generally avoided if possible while breastfeeding, particularly with a newborn or while milk supply is becoming established. Both ingredients enter breast milk, evidence is limited, and pseudoephedrine may reduce milk production; seek professional advice.
pseudoephedrine hydrochloride + triprolidine hydrochloride interactions
Check all prescription, pharmacy and herbal products before use. Important interactions include:
Monoamine oxidase inhibitors and reversible MAO inhibitors, including moclobemide
Concomitant or recent use can cause hypertensive crisis and is contraindicated.
Other sympathomimetic decongestants, including xylometazoline or oxymetazoline
Combined effects may raise blood pressure and increase cardiovascular or nervous-system adverse effects.
Beta blockers and other antihypertensives
Common questions about pseudoephedrine hydrochloride + triprolidine hydrochloride
Answers are fully visible for fast scanning and source review.
What does pseudoephedrine hydrochloride + triprolidine hydrochloride treat?
It relieves upper-respiratory symptoms when congestion occurs with sneezing, runny nose or watery eyes, including in allergic or vasomotor rhinitis, colds and influenza.
Does it make you drowsy?
Yes. Triprolidine can cause drowsiness and impaired concentration, although some people experience restlessness or difficulty sleeping.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.