cyclizine hydrochloride + dipipanone hydrochloride at a glance
Medicine class
Opioid analgesic with an antihistamine antiemetic.
Form
Oral scored tablet containing lactose. The scoreline helps swallowing but does not create equal portions.
Important risk
Dipipanone can cause respiratory depression, tolerance, dependence, addiction and withdrawal.
Driving and alcohol
Do not drive if affected by drowsiness, dizziness or impaired judgement. Avoid alcohol.
What is cyclizine hydrochloride + dipipanone hydrochloride used for?
Licensed uses include:
Moderate to severe pain in medical or surgical conditions where morphine may be indicated.
Prevention of nausea and vomiting associated with opioid analgesics.
How does cyclizine hydrochloride + dipipanone hydrochloride work?
Dipipanone reduces pain signalling in the central nervous system. Cyclizine blocks histamine H1 receptors and has anticholinergic actions, reducing activity in pathways involved in vomiting.
cyclizine hydrochloride + dipipanone hydrochloride preparations and strengths
Tablet
Route: Oral
Strengths: 10 mg + 30 mg
How to take cyclizine hydrochloride + dipipanone hydrochloride
Take only as prescribed. Swallow with water. Do not drink alcohol, share the tablets or stop suddenly; follow the prescriber's stopping plan.
The scoreline helps swallowing but does not create equal portions.
Do not drive or operate machinery if sleepy, dizzy, visually affected or unable to concentrate.
Store securely and out of other people's reach.
cyclizine hydrochloride + dipipanone hydrochloride side effects
Common or expected effects
- Drowsiness or dizziness
- Constipation
- Dry mouth
- Blurred vision
- Headache
- Nausea, indigestion or abdominal discomfort
Get urgent medical advice
- Slow or difficult breathing, profound sedation or loss of consciousness
- Facial, lip, tongue or throat swelling, wheezing or collapse
- Seizures, severe confusion, hallucinations or unusual involuntary movements
- Severe abdominal pain, especially with vomiting or pain spreading to the back
- Yellow skin or eyes, or other signs of liver injury
- Unexpected bruising, bleeding, marked tiredness or recurrent infections
- Inability to pass urine or symptoms of bowel obstruction
cyclizine hydrochloride + dipipanone hydrochloride in pregnancy
The combination is not advised during pregnancy because safety evidence is inadequate. A prescriber should weigh expected benefit against potential harm. Sustained fetal exposure may cause neonatal opioid withdrawal, and use during labour may suppress the baby's breathing.
cyclizine hydrochloride + dipipanone hydrochloride while breastfeeding
Breastfeeding is not recommended. Dipipanone may enter breast milk and cause dangerous sedation or respiratory depression in the infant; advice about cyclizine alone does not establish the combined product's safety.
cyclizine hydrochloride + dipipanone hydrochloride interactions
Check all prescribed, non-prescribed and herbal products before treatment.
Alcohol
May markedly increase sedation, impaired judgement and respiratory depression; avoid it.
Monoamine oxidase inhibitors
May dangerously intensify respiratory depression and cause profound hypotension or coma; concurrent or recent use is contraindicated.
Sedatives, hypnotics, antipsychotics, tricyclic antidepressants, muscle relaxants and gabapentin
May increase central nervous system depression, drowsiness, low blood pressure and breathing impairment.
Common questions about cyclizine hydrochloride + dipipanone hydrochloride
Answers are fully visible for fast scanning and source review.
Why does it contain cyclizine?
Cyclizine helps reduce nausea and vomiting associated with strong opioid pain relief.
Can it cause addiction?
Yes. Dipipanone is an opioid, and dependence or addiction can develop even when taken as prescribed, especially with prolonged use.
Can I stop it suddenly?
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.