buclizine hydrochloride + codeine + paracetamol at a glance
Medicine class
Combination analgesic with a sedating antihistamine antiemetic.
Licensed role
Acute moderate migraine pain with nausea or vomiting when simpler analgesics have not provided adequate relief.
Administration
An oral, film-coated tablet. Follow the pack or prescriber's instructions.
Important ingredient check
Contains paracetamol; do not combine it with another paracetamol-containing product.
Alertness
May cause sleepiness, dizziness and impaired coordination. Avoid alcohol and do not drive if affected.
What is buclizine hydrochloride + codeine + paracetamol used for?
The selected product is licensed for:
Acute moderate pain not relieved by paracetamol, ibuprofen or aspirin alone.
Migraine attacks, including headache, nausea and vomiting.
How does buclizine hydrochloride + codeine + paracetamol work?
Paracetamol reduces pain signalling. Codeine is converted by CYP2D6 to morphine, which acts at opioid receptors; this conversion varies between people. Buclizine blocks histamine H1 receptors and has antimuscarinic and sedating effects that contribute to its anti-nausea action.
How to take buclizine hydrochloride + codeine + paracetamol
Take orally as directed on the pack or by the prescriber. Swallow the film-coated tablet with water. Check pain, cold and migraine products because this combination already contains paracetamol and codeine. Avoid alcohol.
Do not take another paracetamol-containing product at the same time.
Do not share codeine-containing tablets.
Do not drive or use machinery if sleepy, dizzy or cognitively impaired.
buclizine hydrochloride + codeine + paracetamol side effects
Common or expected effects
- Sleepiness
- Headache
- Flushing
- Nausea or vomiting
- Dizziness
- Constipation
- Dry mouth
- Increased sweating
Get urgent medical advice
- Slow or shallow breathing, extreme sleepiness or severe confusion
- Swelling of the face, mouth or throat, wheezing, or difficulty breathing
- Severe or spreading rash, blistering or peeling
- Severe abdominal pain, particularly with vomiting
- Possible liver injury, including yellow skin or eyes, especially after excessive paracetamol exposure
buclizine hydrochloride + codeine + paracetamol in pregnancy
Seek prescriber advice before use. Buclizine evidence is limited, while codeine crosses the placenta and exposure near delivery can cause newborn breathing problems or withdrawal. Do not suddenly stop regularly used codeine without clinical advice.
buclizine hydrochloride + codeine + paracetamol while breastfeeding
Do not use while breastfeeding because it contains codeine. Codeine and its morphine metabolite can enter breast milk and cause dangerous sleepiness, feeding difficulty or respiratory depression in the infant; buclizine safety data are also unavailable.
buclizine hydrochloride + codeine + paracetamol interactions
Check prescribed, pharmacy and non-prescription products before use. Important interactions include:
Other paracetamol-containing products
Can cause unintended overdose and serious liver injury.
Alcohol, benzodiazepines, sedatives, antipsychotics and other CNS depressants
May substantially increase sedation and respiratory depression.
Gabapentin or pregabalin
May cause profound sedation, low blood pressure and respiratory depression.
Common questions about buclizine hydrochloride + codeine + paracetamol
Answers are fully visible for fast scanning and source review.
Can it make me sleepy?
Yes. Codeine and buclizine can cause sleepiness, dizziness and impaired coordination.
Can I drink alcohol while taking it?
No. Alcohol can increase sedation, impaired judgement and respiratory depression.
Can it cause dependence?
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.