calcium chloride + disodium phosphate + magnesium chloride + potassium chloride + sodium chloride + sodium hydrogen carbonate at a glance
Medicine class
Phosphate-containing haemofiltration and haemodialysis solution.
Where it is used
In hospital, using continuous renal replacement equipment under specialist supervision.
Contains glucose
No. Blood glucose may require monitoring during treatment.
What is calcium chloride + disodium phosphate + magnesium chloride + potassium chloride + sodium chloride + sodium hydrogen carbonate used for?
Licensed UK uses include:
Continuous renal replacement therapy for critically ill patients with acute renal failure after pH and potassium have returned to normal, when phosphate replacement is needed because phosphate is lost into the filtrate or dialysate.
Continuous renal replacement therapy when potassium is normal and phosphate is normal or low.
Removal of a medicine or poison that can cross the dialysis or filtration membrane.
How does calcium chloride + disodium phosphate + magnesium chloride + potassium chloride + sodium chloride + sodium hydrogen carbonate work?
The solution supplies water and electrolytes, including phosphate and potassium, to replace losses during filtration. It can also act as dialysis fluid across a membrane, supporting removal of waste and dialysable substances. Bicarbonate helps manage acid–base balance.
How to take calcium chloride + disodium phosphate + magnesium chloride + potassium chloride + sodium chloride + sodium hydrogen carbonate
This solution is not swallowed or self-administered. Trained hospital staff mix both bag compartments and connect the clear, colourless solution to suitable continuous renal replacement equipment using aseptic technique.
It may be used as replacement fluid in the extracorporeal circuit or as dialysate across a semipermeable membrane.
The bag must not be used if it leaks, is damaged, has broken seals before preparation, or contains cloudy or discoloured solution.
Additives should be introduced only after a healthcare professional has assessed compatibility.
calcium chloride + disodium phosphate + magnesium chloride + potassium chloride + sodium chloride + sodium hydrogen carbonate side effects
Common or expected effects
- No effects are classified as common from the available data. Effects reported with unknown frequency include nausea, vomiting, muscle cramps and low blood pressure.
- Fluid imbalance, electrolyte disturbance, and metabolic acidosis or alkalosis may occur.
Get urgent medical advice
- Severe fluid overload, which may cause breathing difficulty, swelling or heart failure.
- Marked fluid depletion or low blood pressure causing collapse or reduced organ perfusion.
- Clinically important potassium, phosphate, calcium, glucose or acid–base abnormalities.
- Sepsis or shock if contaminated solution is administered.
calcium chloride + disodium phosphate + magnesium chloride + potassium chloride + sodium chloride + sodium hydrogen carbonate in pregnancy
There are no documented clinical data for this product during pregnancy. It should be used only when clearly needed, with treatment selected and monitored by specialist critical-care and obstetric teams.
calcium chloride + disodium phosphate + magnesium chloride + potassium chloride + sodium chloride + sodium hydrogen carbonate while breastfeeding
There are no documented clinical data during breastfeeding. Use should be limited to situations where it is clearly needed and assessed by the treating specialist team.
calcium chloride + disodium phosphate + magnesium chloride + potassium chloride + sodium chloride + sodium hydrogen carbonate interactions
Continuous renal replacement therapy and the solution’s electrolytes can affect other treatments:
Filterable or dialysable medicines
The filter may lower their blood concentrations, so clinical review and drug-level monitoring may be needed where appropriate.
Phosphate-containing nutrition or fluids
Additional phosphate increases the risk of hyperphosphataemia.
Vitamin D analogues and calcium-containing products
Combined use can increase the risk of hypercalcaemia.
Common questions about calcium chloride + disodium phosphate + magnesium chloride + potassium chloride + sodium chloride + sodium hydrogen carbonate
Answers are fully visible for fast scanning and source review.
Is Phoxilium taken by mouth?
No. It is a hospital-only solution connected to continuous renal replacement equipment by trained staff.
Why does Phoxilium contain phosphate?
Phosphate can be lost into the filtrate or dialysate during continuous treatment. This solution helps replace that loss when phosphate is normal or low.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.