alanine + arginine + aspartic acid + 24 other active ingredients at a glance
Medicine class
Combined neonatal parenteral nutrition
Licensed use
Nutrition for preterm newborns who cannot receive enough nutrition orally or through the gut
Administration
Intravenous infusion prepared and managed by a neonatal healthcare team
Main components
Amino acids, glucose and electrolytes, with an optional lipid chamber
What is alanine + arginine + aspartic acid + 24 other active ingredients used for?
Its UK-licensed indication is:
Parenteral nutrition in preterm newborn infants when oral or enteral nutrition is impossible, insufficient or contraindicated.
How does alanine + arginine + aspartic acid + 24 other active ingredients work?
Amino acids provide building blocks for protein synthesis and growth. Glucose and fats provide energy, while electrolytes support fluid balance and normal cellular functions. These nutrients enter the bloodstream directly, bypassing the digestive tract.
How to take alanine + arginine + aspartic acid + 24 other active ingredients
This product is not taken by mouth. Trained staff mix the required chambers, inspect the preparation and administer it through an intravenous line using an infusion pump. The bag and administration set must be protected from light. Undiluted product requires central venous administration.
Do not use a damaged bag or one containing particles or a separated lipid emulsion.
A filter is recommended during administration.
Parents and carers should not adjust the pump or disconnect the infusion.
alanine + arginine + aspartic acid + 24 other active ingredients side effects
Common or expected effects
- Low blood phosphate
- High blood glucose
- High blood calcium
- High blood triglycerides
- Low blood sodium
Get urgent medical advice
- Allergic reaction, including rash, fever, shivering or breathing difficulty
- Respiratory distress from vascular precipitates or fat overload
- Leakage outside the vein, which can cause soft-tissue injury or skin necrosis
- Catheter-associated infection or sepsis
- Cholestasis or deteriorating liver function
alanine + arginine + aspartic acid + 24 other active ingredients in pregnancy
Pregnancy information is not applicable because this formulation is licensed for preterm newborn infants, not a pregnant person.
alanine + arginine + aspartic acid + 24 other active ingredients while breastfeeding
Breastfeeding information is not applicable to the recipient because the product is given directly to a preterm newborn. Its use may overlap with gradual introduction of milk feeds under neonatal supervision.
alanine + arginine + aspartic acid + 24 other active ingredients interactions
Important medicine and administration interactions include:
Ceftriaxone
Contraindicated in preterm newborns because calcium–ceftriaxone precipitates can form, even when separate infusion lines are used.
Potassium-sparing diuretics, ACE inhibitors, angiotensin-II receptor blockers, tacrolimus or ciclosporin
May increase the risk of high blood potassium because the formulation contains potassium.
Coumarin anticoagulants, including warfarin
Vitamin K naturally present in the oils may reduce anticoagulant activity.
Common questions about alanine + arginine + aspartic acid + 24 other active ingredients
Answers are fully visible for fast scanning and source review.
What is this used for?
It provides intravenous nutrition to preterm newborns when feeding by mouth or through the gut is impossible, insufficient or contraindicated.
Is it a milk feed?
No. It is parenteral nutrition given into a vein and may be used while milk feeds are unsuitable or being introduced.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.