Acoramidis at a glance
Medicine class
Transthyretin (TTR) stabiliser.
Licensed use
Wild-type or variant ATTR-CM in adults.
Administration
Swallow the film-coated tablets whole with water, with or without food.
Additional monitoring
Beyonttra carries the black-triangle symbol, encouraging prompt reporting of suspected side effects.
What is Acoramidis used for?
Acoramidis is licensed for:
Wild-type or variant transthyretin amyloidosis in adults with cardiomyopathy (ATTR-CM).
How does Acoramidis work?
In ATTR-CM, the four-part transthyretin protein can separate into unstable components that misfold and form amyloid deposits in the heart. Acoramidis binds to and stabilises transthyretin, reducing this separation and slowing amyloid formation.
Acoramidis preparations and strengths
Tablet
Route: Oral
Strengths: 356 mg
How to take Acoramidis
Follow the prescription label and specialist team's instructions.
Swallow the film-coated tablets whole.
Take with water, with or without food.
Acoramidis side effects
Common or expected effects
- Diarrhoea.
- Gout, causing painful joint inflammation.
Get urgent medical advice
- Severe allergic reaction, including sudden facial, mouth or throat swelling, breathing difficulty, faintness or collapse.
Acoramidis in pregnancy
There are no data from pregnant women, and animal studies found developmental toxicity alongside maternal toxicity. Acoramidis is not recommended during pregnancy or for women who could become pregnant and are not using contraception. Discuss pregnancy planning or suspected pregnancy promptly with the prescriber.
Acoramidis while breastfeeding
It is unknown whether acoramidis or its metabolites enter human milk, and a risk to the infant cannot be excluded. The UK product information states that it should not be used during breastfeeding.
Acoramidis interactions
Give the prescriber and pharmacist a complete medicines list. Important considerations include:
CYP2C8 or CYP2C9 substrates with a narrow therapeutic index
Use cautiously because acoramidis inhibited these enzymes in laboratory studies; the clinical effect has not been tested in an interaction study.
Gastric acid-reducing medicines
A dedicated interaction study has not been performed, although the main clinical study found no difference in acoramidis exposure or TTR stabilisation.
Diuretics
Population pharmacokinetic analysis did not indicate an effect on steady-state acoramidis concentrations.
Common questions about Acoramidis
Answers are fully visible for fast scanning and source review.
Is acoramidis hydrochloride the same medicine as Beyonttra?
Yes. Beyonttra is a brand name for a UK product containing acoramidis hydrochloride.
What type of amyloidosis does it treat?
It is licensed for adults with cardiomyopathy caused by wild-type or variant transthyretin amyloidosis.
Does acoramidis cure ATTR-CM?
It is not described as a cure. It stabilises transthyretin to slow the amyloid-forming disease process.
Can the tablets be taken with food?
Yes. They may be taken with or without food.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.