Answer
Acoramidis mimics the protective T119M variant by forming hydrogen bonds with adjacent serine residues within both thyroxine-binding sites of the transthyretin tetramer, stabilising it against dissociation into monomers and thereby slowing the amyloidogenic process in ATTR cardiomyopathy.
Sources for this answer
- BEYONTTRA 356 mg film-coated tabletsBayer plc · emc · SmPC §5.1 Pharmacodynamic properties · Version 1Document updated
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