Answer
Valproate semisodium (Depakote) reduces lamotrigine metabolism and nearly doubles its mean half-life, potentially increasing lamotrigine toxicity, particularly serious skin rashes; clinical monitoring is recommended, with lamotrigine dose reduction when appropriate.
Sources for this answer
- Depakote 250mg TabletsSANOFI · emc · SmPC §4.5 Interaction with other medicinal products · Version 32Document updated
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