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Medicines valproate semisodiumQuestion & answer

valproate semisodium · Medicine question

Can valproate semisodium affect male fertility?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Yes, valproate semisodium (Depakote) carries a risk of infertility in males.

Sources for this answer

Depakote 250mg TabletsSANOFI · emc · SmPC §4.2 Posology and method of administration · Version 32Document updated 2 October 2026

Sources checked 8 November 2026

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The full medicine guide

valproate semisodium

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More questions about valproate semisodium

Has the efficacy of valproate semisodium (Depakote) for manic episodes in bipolar disorder been established in children under 18?How can oestrogen-containing hormonal contraceptives affect the efficacy of valproate semisodium?Can valproate semisodium cause severe pancreatitis?How much sodium does each Depakote 250 mg tablet containing valproate semisodium contain?Is valproate semisodium (Depakote) contraindicated in people with active liver disease?

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