Answer
Metformin in Xigduo lowers basal and post-meal glucose without stimulating insulin secretion or causing hypoglycaemia; it may inhibit hepatic gluconeogenesis and glycogenolysis, modestly improve insulin sensitivity and muscle glucose uptake/use, and delay intestinal glucose absorption, while stimulating glycogen synthesis and increasing GLUT-1/GLUT-4 transport capacity.
Sources for this answer
- Xigduo 5 mg/850 mg film-coated tabletsAstraZeneca UK Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 27Document updated
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