Answer
Cimetidine may increase exposure to the metformin component of Xigduo by competing for renal tubular transport systems, so close monitoring of glycaemic control, dose adjustment within recommended limits and changes in diabetes treatment should be considered.
Sources for this answer
- Xigduo 5 mg/850 mg film-coated tabletsAstraZeneca UK Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 26Document updated
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