Can diabetic ketoacidosis occur with Xigduo (dapagliflozin/metformin) when blood glucose is only moderately raised?

Yes, rare diabetic ketoacidosis, including life-threatening and fatal cases, has been reported with dapagliflozin, a component of Xigduo, sometimes with blood glucose only moderately raised, below 14 mmol/L (250 mg/dL), so suggestive symptoms require immediate assessment regardless of glucose level.