Answer
Concomitant methotrexate increases steady-state trough concentrations of golimumab in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis, but available data do not suggest a need to adjust either medicine’s dose.
Sources for this answer
- Simponi 50 mg solution for injection in pre filled syringeJanssen-Cilag Ltd (a Johnson & Johnson Company) · emc · SmPC §4.5 Interaction with other medicinal products · Version 41Document updated
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