Answer
The piperacillin component of piperacillin + tazobactam may reduce methotrexate excretion, so serum methotrexate levels should be monitored to avoid toxicity.
Sources for this answer
- Piperacillin/Tazobactam 4 g/0.5 g powder for solution for infusionReig Jofre UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 2Document updated
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