tolbutamide · Medicine question

Why should tolbutamide not be taken with warfarin?

iatroX medicinesPublished 8 November 2026

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Tolbutamide should not be taken with warfarin because this coumarin anticoagulant may enhance its blood-glucose-lowering effect, and severe hypoglycaemic reactions have occurred with coumarins.

Sources for this answer

Tolbutamide Tablets BP 500mgSovereign Medical · emc · SmPC §4.5 Interaction with other medicinal products · Version 2Document updated 3 February 2026

Sources checked 8 November 2026

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