tolbutamide · Medicine question

How does tolbutamide increase insulin secretion?

iatroX medicinesPublished 8 November 2026

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Tolbutamide initially increases insulin secretion by functioning pancreatic islet beta cells, apparently through inhibition of ATP-sensitive potassium channels.

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Tolbutamide Tablets BP 500mgSovereign Medical · emc · SmPC §5.1 Pharmacodynamic properties · Version 2Document updated 3 February 2026

Sources checked 8 November 2026

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