Answer
Rifampicin, a strong CYP3A4 inducer, should be avoided with avacopan because it reduces avacopan exposure (AUC) by approximately 93% and peak plasma concentration by 79%, potentially causing loss of efficacy.
Sources for this answer
- Avacopan Vifor 10 mg hard capsulesVifor Fresenius Medical Care Renal Pharma UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 7Document updated
Sources checked